Contact Information

 

Medical School Address:

 

Nelson Clinic 2nd Floor

Department of Psychiatry

Medical College of Virginia

P.O. Box 980710

Richmond, VA 23298

(804) 828-9452

 

Private Practice:

 

Family Institute of Virginia

2910 Monument Avenue

Richmond, VA  23221

(804) 355-6876

 

Education

 

Bachelor of Science, June 1958

Duke University

Durham, North Carolina

 

Doctorate of Medicine, June 1964

Duke University School of Medicine

Durham, North Carolina

 

 

Military Service

 

1965 – 1967 Lieutenant Commander, United States Public Health Service

 

 

Licensure and Certification

 

Virginia No. 28839 (1977)

 

American Board of Psychiatry and Neurology, No. 12140 (1972)

 

 

Postdoctoral Training

 

1967 – 1970 Residency, Department of Psychiatry, Duke University Medical Center, Durham, North Carolina

 

1965 –  1967 Staff Associate in Biochemistry, National Institute of Mental Health, Bethesda, Maryland

 

1964 –  1965 Internship, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina

 

Hospital and Other (Non-Academic) Appointments

 

2001- present MCV Hospital, Richmond, Virginia

 

1992 – 2001 Psychiatrist-in-Chief, UAB Hospital, Birmingham, Alabama

 

1990 Senior Vice President, Clinical Services and Research, Physician-in-Chief, Board of Directors, Charter Medical Corporation, Macon, Georgia

 

1987 – 1990 Vice President, Psychiatric Medicine and Research, Psychiatrist-

in-Chief, Charter Medical Corporation, Macon, Georgia

 

1985 – 1987 Vice President, Psychiatric Medicine, Charter Medical Corporation, Macon, Georgia, and Medical Director, Charter Westbrook Hospital, Richmond, Virginia

 

1984 – 1985 Psychiatrist-in-Chief, University of Michigan Hospital, Ann Arbor, Michigan

 

1982 – 1984 Acting Director, Virginia Treatment Center for Children, Richmond, Virginia

 

1977 – 1984 Psychiatrist-in-Chief, Medical College of Virginia Hospital, Richmond, Virginia

 

Professional Consultantships

 

Pfizer Inc.

Janssen Pharmaceutica Inc. 

Bristol-Myers Squibb Company

 

Academic Appointments

 

June 2001- present        Distinguished Clinical Professor of Psychiatry, Director, MCV Borderline Personality Disorder Program, Medical College of  Virginia, Virginia Commonwealth University, Richmond, Virginia

 

June 2001-present          Professor Emeritus, University of Alabama School of Medicine, Birmingham, Alabama

 

Jan 1992 – June 2001 Heman E. Drummond Professor and Chairman, Department of Psychiatry and Behavioral Neurobiology, University of Alabama School of Medicine, Birmingham, Alabama

 

Aug 1985 – June 2001 Clinical Professor, Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia

 

May 1984 – Jan 1985 Professor and Chairman, Department of Psychiatry, and Executive Director, Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan

 

Aug 1977 – May 1984 Professor and Chairman, Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia

 

July 1975 – July 1977 Vice-Chairman and Director of Clinical Services, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington

 

July 1974 – July 1977 Associate Professor of Psychiatry and Pharmacology; Director, Division of Psychopharmacology, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington

 

Sept 1973 – June 1974 Associate Professor of Psychiatry, Assistant Professor of Pharmacology, Department of Psychiatry, Duke University Medical Center, Durham, North Carolina

 

July 1970 – Sept 1973 Assistant Professor of Psychiatry and Pharmacology, Department of Psychiatry, Duke University Medical Center, Durham, North Carolina

 

 

Awards and Honors

 

1961 L. A. Smith Scholastic Award

1963 Alpha Omega Alpha Honors Medical Society

1969 - 1970 Virginia Ware Gibbons Scholar in Biological Psychiatry

1969 - 1970 American Psychiatric Association Falk Fellow

1970 - 1975 NIMH Research Scientist Development Award

1990 National Mental Health Association Award for Dedicated

Volunteer Service

 

Professional Societies

 

American College of Psychiatrists

American Psychiatric Association – Distinguished Life Fellow

American Medical Association

American College of Neuropsychopharmacology-Life Member

American Society for Pharmacology and Experimental Therapeutics

American Society for Neurochemistry 

American Association for the Advancement of Science

American Federation for Clinical Research

Society of Biological Psychiatry

American Psychopathological Association

American Society for Clinical Pharmacology and Therapeutics

Psychiatric Society of Virginia

 

Councils And Committees

 

2003- Scientific Advisory Board, National Education Alliance for Borderline Personality Disorder (NEA-BPD)

 

2000- Dean’s Award Committee, American College of Psychiatrists

 

NIH Consensus Development Panel.  Effective Medical Treatment of Opiate Addiction.  Bethesda, MD, Nov. 17-19, 1997

 

1995 Workshop on “Managed Mental Health Care in Academic Centers,”

American Psychiatric Association

 

1995 Ethics Committee, American College of Neuropsychopharmacology

 

1990 Medical Use Task Force, Joint Commission on Accreditation of Healthcare Organizations

 

1988 - 1994 Chairman, Committee on Finance and Marketing, American Psychiatric Association

 

1988 - 1992 Mental Health Services Committee, Group for the Advancement of Psychiatry

 

1988 - 1991 Advisory Board, Institute for Behavioral Healthcare

 

1987 - 1993 Board of Directors, National Mental Health Association

 

1986 - 1994 Scientific Advisory Board, National Depressive and Manic Depressive Association

 

1988 - 1991 Ethics Committee, National Association of Private Psychiatric Hospitals

 

1989 - 1992 Vice-Chairman, Psychiatric Hospitals Committee, Federation of American Health Systems

 

1985 - 1988 Academic Psychiatry Consortium

 

1982 - 1986 Veterans Administration Schizophrenia Biological Research Centers Oversight Committee

 

1984 - 1985 Academic Chairmen’s Advisory Board, Department of Mental Health, State of Michigan

 

1982 - 1985 Veterans Administration Review Committee on Behavioral Research

 

1980 - 1984 Committee on Mental Health, Medical Society of Virginia

 

1978 - 1984 Chairmen’s Advisory Committee, Department of Mental Health and Mental Retardation, State of Virginia

 

1977 - 1982 NIMH Clinical Psychopharmacology Research Review Committee

 

1974 - 1977 Advisory Board, Department of Mental Health, State of Washington

 

University Activities

 

1994 - 1995 Chair, University of Alabama Health Services Foundation Advisory Committee

 

1994 - 1998 University of Alabama Health Services Foundation Executive Committee

 

1995 Chair, University of Alabama Health Services Foundation Managed Care Committee

 

1992 - present UAB Hospital Medical/Dental Staff Executive Committee

 

1992 - present Executive Committee of the Clinical Chairs

 

1992 - present Combined Executive Committee:  Clinical and Joint Health Service Chairs

 

1995 - 1997 Information Technology Advisory Group (ITAG)

 

 

Editorial Board Memberships

 

2003 – present         Current Psychosis and Therapeutics (Founding Editor-in-Chief)

1999 – present Current Psychiatry Reports (Founding Editor-in- Chief)

1985 - 1994 Hospital and Community Psychiatry

1980 - present Journal of Clinical Psychopharmacology

1978 - 1988 Journal of Clinical Psychiatry

Bibliography

 

 

Friedel, R.O., Brown, J.D., and Durell, J.:  Monophosphatidylinositolphosphohydrolase in guinea pig brain.  Biochem. Biophys. Acta, 144: 684-686, 1967.

 

Durell, J., Sodd, M.A., and Friedel, R.O.: Acetylcholine stimulation of the phosphodiesteratic cleavage of guinea pig brain phosphoinositides.  Life Sciences, 7: 363-386, 1968.

 

Friedel, R.O., Brown, J.D., and Durell, J.: The enzymic hydrolysis of phosphatidylinositol by guinea pig brain: Subcellular distribution and hydrolysis products.  J. Neurochem., 16: 371-378, 1969.

 

Durell, J., Garland, J.T. and Friedel, R.O.: Acetylcholine action: Biochemical aspects.  Science, 165: 862-866, 1969.

 

Bressler, B., and Friedel, R.O.:  A comparison between chlorpromazine and thiothixene in a Veterans Administration Hospital population.  Psychosomatics, 12: 275-277, 1971.

 

Friedel, R.O. and Schanberg, S.M.:  Incorporation in vivo of intracisternally injected 33PI into phospholipids of rat brain.  J. Neurochem., 18: 2191-2200, 1971.

 

Friedel, R.O. and Schanberg, S.M.: Effects of carbamylcholine and atropine on incorporation in vivo of intracisternally injected 33PI into phospholipids of rat brain.  J. Pharmacol. Exp. Ther., 183: 326-332, 1972.

 

Friedel, R.O., Johnson, J. and Schanberg, SM.:  Effects of sympathomimetic drugs on incorporation in vivo of intracisternally injected 33PI into phospholipids of rat brain.  J. Pharmacol. Exp. Ther., 184: 585-589, 1973.

 

Friedel, R.O., Berry, D.E. and Schanberg, S.M.:  Effects of dopamine and norepinephrine on phospholipid metabolism of rat brain in vivo: Regional differences.  J. Neurochem., 22: 873-875, 1974.

 

Friedel, R.O. and Schanberg, S.M.:  Effects of histamine on phospholipid metabolism of rat brain in vivo.  J. Neurochem., 24: 189-190, 1975.

 

Bielski, R.M. and Friedel, R.O.:  Prediction of tricyclic antidepressant response: A critical review.  Arch. Gen. Psychiatry, 33: 1479-1489, 1976.

 

Friedel, R.O.:  Relationship of pharmacological models of bioavailability of cloropromazine with drug and metabolite blood levels.  Psychopharmacol. Bull., 12 (4): 63-64, 1976.

 

Friedel, R.O., Slotnick, R.N., and Bombardt, P.A.:  Effects of γ-aminobutyric acid on 33Pi incorporation into rat brain phospholipids in vivo.  Life Sciences, 20: 235-242, 1977.

 

Bombardt, P.A. and Friedel, R.O.:  A GC/CIMS assay for the cis and trans isomers of tiothixene in human plasma.  Comm. Psychopharmacol., 1: 49-60, 1977.

 

Bielski, R.J., and Friedel, R.O.:  Subtypes of depression - diagnosis and medical management.  West. J. Med., 126: 347-352, 1977.

 

Jenkins, R.G. and Friedel, R.O.:  Analysis of tricyclic antidepressants in human plasma by GC/CIMS with selected ion monitoring.  J. Pharm. Sci., 67: 17-23, 1978.

 

Soukup, J.F., and Friedel, R.O.:  Cholinergic stimulation of polyphosphoinositide metabolism in brain in vivo.  Biochem. Pharmacol., 27: 1239-1243, 1978.

 

Soukup, J.F., Friedel, R.O., and Schanberg, S.M.:  Microwave irradiation fixation for studies of polyphosphoinositide metabolism in brain.  J. Neurochem., 30: 635-637, 1978.

 

Brinkley, J.R., Beitman, B.D., and Friedel, R.O.: Use of low-dose neuroleptic regimens in the treatment of borderline patients.  Arch. Gen. Psychiatry, 36: 319-326, 1979.

 

Lin, K.M., and Friedel, R.O.:  Relationship of plasma levels of chlordiazepoxide and metabolites to clinical response.  Am. J. Psychiatry, 136: 18-23, 1979.

 

Ward, N.G., Bloom, V.L., and Friedel, R.O.:  The effectiveness of tricyclic antidepressants in chronic depression.  J. Clin. Psychiatry, 49: 49-52, 1979.

 

Narasimhachari, N., and Friedel, R.O.:  N-alylation of secondary amine tricyclic antidepressants as a general method for their quantitation by GC-MS-SIM technique.  Preparation of N-ethyl derivatives of desipramine, nortriptyline, protriptyline, and desmethyldoxepin.  Anal. Lett. 12(B1): 77-88, 1979.

 

Friedel, R.O., Veith, R.C., Bloom, V., and Bielski, R.J.:  Desipramine plasma levels and clinical response in depressed outpatients.  Comm. Psychopharmacol., 3: 81-87, 1979.

 

Silverman, J.J., Brennan, P., and Friedel, R.O.:  Tricyclic plasma levels:  Clinical significance.  Psychosomatics, 20: 11: 736-746, 1979.

 

Narasimhachari, N., Friedel, R.O., Schlemmer, F., and Davis, J.M.:  Quantitation of amphetamine in plasma and cerebrospinal fluid by gas chromatography-mass spectrometry-selected ion monitoring, using methylphenethylamine as an internal standard.  J. Chromatography, 164: 386-393, 1979.

 

Narasimhachari, N., Friedel, R.O., and Saady, J.J.:  Improved tricyclic antidepressant assay by GC/MS.  Res. Comm. Psychol. Psychiat. & Behav., 4(4): 477-490, 1979.

 

Narasimhachari, N., and Friedel, R.O.:  A precautionary note regarding derivatization of secondary amines and dialkylacetals of formamide other than the diethyl derivative.  Anal. Lett. 12(A12): 1293-1304, 1979.

 

Friedel, R.O.:  The pharmacotherapy of depression in the elderly: pharmacokinetic considerations.  Proc. Amer. Psychopath. Assoc., 69: 157-165, 1980.

 

Narasimhachari, N., and Friedel, R.O.:  A precautionary note regarding derivatization of secondary amines and dialkylacetals of formamide other than the diethyl derivative: A correction.  Anal. Lett., 13(13A): 203-204, 1980.

 

Narasimhachari, N., and Friedel, R.O.:  GC-MS studies of phenelzine and its acyl derivatives.  Res. Comm. Psychol. Psychiat. & Behav., 5(2): 185-197, 1980.

 

Saady, J.J., Narasimhachari, N., and Friedel, R.O.:  Unsuspected impurities in imipramine and desipramine standards and pharmaceutical formulations.  Clin. Chem., 21: 343, 1980.

 

Veith, R.C., Friedel, R.O., Bloom, V. and Beilski, R.:  Electrocardiogram changes and plasma desipramine levels during treatment of depression.  Clin. Pharmacol. Ther., 27(6): 796-802, 1980.

 

Narasimhachari, N., and Friedel, R.O.:  Quantitation of biologically important primary amines as their isothiocyanate derivatives by gas chromatography using nitrogen detector and cross validation by selected ion monitoring.  Clin. Chem. Act., 110: 235-243, 1981.

 

Reifler, B.V., Ward, N., David, C.M., and Friedel, R.O.:  Thiothixene plasma levels and clinical response in acute schizophrenia.  J. Clin. Psychiatry, 42(5): 207-211, 1981.

 

Friedel, R.O., and Knauer, G.:  Actions of neuroleptics on the acetylcholine-induced phospholipid effect in rat neostriatal homogenates.  Neuropharmacology, 20: 925-930, 1981.

 

Narasimhachari, N., Saady, J., and Friedel, R.O.:  Quantitative mapping of metabolites of imipramine and desipramine in plasma samples by gas chromatographic mass spectrometry.  Biol. Psychiatry, 16: 937-944, 1981.

 

Saady, J.J.., Bloom, V.L., Narasimhachari, N., Goldberg, S.C. and Friedel, R.O.:  A comparison of plasma levels of two tricyclic antidepressants: imipramine and desipramine.  Psychopharmacology, 75: 173-174, 1981.

 

 

Narasimhachari, N., Boadle-Biber, M.C. and Friedel, R.O.:  A critical evaluation of LC-EC for the simultaneous determination of 5-hydroxytryptophan, 5-HT, 5-HIAA and HVA in biological samples using GC-MS for validation.  Res. Comm. Chem. Path. & Pharmacol., 37: 413-430, 1982.

 

Tilley, D.H., Goldberg, S.C. and Friedel, R.O.:  Current knowledge of tricyclic antidepressant response indicators.  Psychopharmacol. Bull., 18: 132-135, 1982.

 

Friedel, R.O.:  Influence of old age on the effects of drugs: introduction.  Gerontology, 28 Suppl. 1: 5-7, 1982.

 

Mumtaz, M., Narasimhachari, N., Friedel, R.O., Pandey, G.M. and Davis, J.M.:  Evaluation of fluorometric assay methods for serotonin in platelets.  Plasma and whole blood samples by comparison with GC-MS-SIM technique.  Res. Comm. Chem. Path. & Pharmacol., 36: 45-60, 1982.

 

Friedel, R.O.:  Subtypes and laboratory measures of autonomous depression.  J. Clin. Psychiatry, 43(8 Pt 2): 28-31, 1982.

 

Ward, N.G., Bloom, V.I., Dworkin, S., Fawcett, J., Narasimhachari, N. and Friedel, R.O.:  Psychobiological markers in coexisting pain and depression:  toward a unified theory.  J. Clin. Psychiatry, 43: 32-41, 1982.

 

Bogena, S.C., Narasimhachari, N., Mumtaz, M., Goldin, S., and Friedel, R.O.:  Separation of quantitation of cis- and trans-thiothixene in human plasma by high-performance liquid chromatography.  J. Chromatography, 233: 257-267, 1982.

 

Mumtaz, M., Narasimhachari, N., and Friedel, R.O.:  Assay of trace amines by gas chromatography with nitrogen detector in biological samples using C18 SEP-PAK cartridges for sample cleanup.  Analytical Biochem., 126: 365-373, 1982.

 

Schulz, S.C., Killer, M.M., Kishore, P.R., Hamer, R.M., Gehl, J.J. and Friedel, R.O.:  Ventricular enlargement in teenage patients with schizophrenia spectrum disorder.  Am. J. Psychiatry, 140: 1592-1595, 1983.

 

Veith, R.C., Bloom, V., Bielski, R. and Friedel, R.O.:  ECG effects of comparable plasma concentrations of desipramine and amitriptyline.  J. Clin. Psychopharm., 2(6): 394-398, 1982.

 

Narasimhachari, N., Saady, J.J., Joseph, A., Ettigi, P., and Friedel, R.O.:  Evidence for in vivo methylation of the secondary amino antidepressant desipramine to imipramine in humans.  J. Clin. Psychopharm., 2(6): 413-416, 1982.

 

Friedel, R.O.:  Diagnosis and treatment of autonomous depression in the geriatric patient.  Geriatric Med. Today 2(1): 4051, 1983.

Ward, N.G., Bloom, V.L., Fawcett, J., and Friedel, R.O.:  Urinary methoxy-4-hydroxy-phenethylene glycol in the prediction of pain and depression relief with doxepin: preliminary findings.  J. Nerv. Ment. Disease, 171(1): 55-58, 1983.

 

Veith, R.C., Bielski, R.J., Bloom, V., Fawcett, J.A., Narasimhachari, N. and Friedel, R.O.:  Urinary MHPG excretion and treatment with desipramine or amitriptyline: Prediction of response, effect of treatment and methodological hazards.  J. Clin. Psychopharm., 3(1): 18-27, 1983.

 

Tilley, D.H., Goldberg, S.C., Friedel, R.O., and Hamer, R.M.:  Therapeutic practice with tricyclic antidepressants among experts and general practice psychiatrists.  Neuropharmacol., 22(4): 543-548, 1983.

 

Schulz, S.C., Sinicropte, P., Kishore, P. and Friedel, R.O.:  Treatment response and ventricular brain enlargement in young schizophrenic patients.  Psychopharmacol. Bull., 19(3): 510-512, 1983.

 

Schulz, S.C., Butterfield, L., Garicano, M., Narasimhachari, N. and Friedel, R.O.:  Beyond the therapeutic window: a case presentation.  J. Clin. Psychiatry, 44(5): 223-225, 1984.

 

Boyer, W.F. and Friedel, R.O.:  Antidepressant and antispychotic plasma levels.  Psychiatric Clinics of North America, 7(3): 601-610, 1984.

 

Narasimhachari, N., Dorey, R.C., Landa, B.L. and Friedel, R.O.:  Improved high-performance liquid chromatographic method for the quantitation of cis-thiothixene in plasma samples using trans-thiothixene as internal standard.  J. Chromatography, 311: 424-429, 1984.

 

Levenson, J.L. and Friedel, R.O.:  Major depression in patients with cardiac disease:  diagnosis and somatic treatment.  Psychosomatics, 26: 92-102, 1985.

 

Schulz, P.M., Schulz, S.C., Hamer, R., Resnick, R.J., Friedel, R.O. and Goldberg, S.C.:  The impact of borderline and schizotypal personality disorders on patients and their families.  Hosp. & Comm. Psychiatry, 38(8): 879-881, 1985.

 

Schulz, S.C., Schulz, P.M., Dommissee, C., Hamer, R.M., Blackard, W.G., Narasimhachari, N., and Friedel, R.O.: Amphetamine response in borderline patients.  Psychiat. Res., 15: 97-108, 1985.

 

Friedel, R.O.:  Use of anxiolytics: prescribing practices.  IM-Internal Medicine for the Specialist, special issue, 1985.

 

Friedel, R.O.:  Bioavailability and bioequivalency of neuroleptics.  Integrative Psychiatry, 3: 63S-68S, 1985.

Jennings, W.S., Jr., Schulz, S.C., Narasimhachari, N., Hamer, R.M. and Friedel, R.O.: Brain ventricular size and CSF monoamine metabolites in an adolescent inpatient population.  Psychiatry Research, 16: 87-94, 1985.

 

Goldberg, S.C., Schulz, S.C., Schulz, P.M., Resnick, R.J., Hamer, R.M. and Friedel, R.O.: Borderline and schizotypal personality disorders treated with low-dose thiothixene vs. placebo.  Arch. Gen. Psychiatry, 43: 680-686, 1986.

 

Goldberg, S.C., Ettigi, P., Schulz, P.M., Hamer, R.M., Hayes, P.E. and Friedel, R.O.:  Alprazolam vs. imipramine in depressed outpatients with neurovegetative signs.  J. Affect. Dis., 11(2): 139-145, 1986.

 

Schulz, P.M., Schulz, S.C., Goldberg, S.C., Ettigi, P., Resnick, R.J. and Friedel, R.O.:  Diagnosis of the relatives of schizotypal outpatients.  J. Nerv. Ment. Disease, 174: 457-463, 1986.

 

Friedel, R.O.: The combined use of neuroleptics and ECT in drug-resistant schizophrenic patients.  Psychopharmacol. Bull. 22(3): 930-938, 1986.

 

Goldberg, S.C., Tilley, D.H., Friedel, R.O., Hamer, R.M. and Ban, T.A.:  A survey of psychiatrists’ practices related to the use of tricyclic antidepressants.  Hosp. & Comm. Psychiatry, 37(12): 1247-1251, 1986.

 

Goldberg, S.C., Tilley, D.H., Friedel, R.O., Hamer, R.M., Ban, T.A., Brockett, C., Bale, P. and Stephens, V.:  Who will benefit from tricyclic antidepressants: a survey.  J. Clin. Psychiatry, 49: 224-228, 1988.

 

Resnick, R.J., Goldberg, S.C., Schulz, S.C., Schulz, P.M., Hamer, R.M. and Friedel, R.O.:  Borderline personality disorder: Replication of MMPI profiles.  J. Clin. Psychol., 44(3): 354-360, 1988.

 

Friedel, R.O., Adding quality to the healthcare cost equation. Hospital & Community Psychiatry. 42(7): 673, 1991.

 

Friedel, R.O. (with NIH Consensus Development Panel): Effective medical treatment of opiate addiction.  NIH Consensus Statement, Nov. 17-19, 15(6): 1-38, 1997

 

Friedel, R.O.: Introduction to Current Psychiatry Reports. Current Psychiatry Reports, 1:1, 1999.

 

Friedel, R.O.: The future of psychiatry is here. Current Psychiatry Reports, 1:99, 1999. 

 

Friedel, R.O.: Dopamine Dysfunction in Borderline Personality Disorder: A Hypothesis.  Neuropsychopharmacology. In Press.

 

Books  

 

Baxter, L.R. and Friedel, R.O. (eds): Current Psychiatric Diagnosis & Treatment. Williams and Wilkins, Philadelphia, 1998.

 

Friedel, RO:  Borderline Personality Disorder Demystified.  Avalon Publishing Group, 2004.

 

Publications and Chapters

 

Hine, F.R.,  Pfeiffer, E., Maddox, G., Hein P. and Friedel, R.O.:  Behavioral Sciences:  A Selective View.  Little, Brown and Co., Boston, 1972.

 

Friedel, R.O.:   Norepinephrine, dopamine and serotonin:  CNS distribution, biosynthesis and metabolism.  In C. Eisdorfer and W.E. Fann (eds.), Psychopharmacology and Aging, Plenum Press, NY, 11-15, 1973.

 

Friedel, R.O.:   Biochemical basis of psychopharmacology.  In W.E. Fann and G. Maddox (eds.), Drug Issues in Geropsychiatry.  Williams & Wilkins Co., Baltimore, 9-17, 1974.

 

Friedel, R.O.: and Raskind, M.A.:  Relationship of blood levels of Sinequan to clinical effects in the treatment of depression in aged patients.  In J. Mendels (ed.), SinequanR (doxepin):  A Monograph of Recent Clinical Studies.  Excerpta Medica, Princeton, 51-53, 1975.

 

Friedel, R.O. and Bielski, R.J.:  Prediction of response to antidepressant medications.  Weekly Psychiatry Update Series No. 12, 1976.

 

Eisdorfer, C. and Friedel, R.O.:   Developmental psychopharmacology:  Aging.  In M. Jarvik (ed.), Psychopharmacology in the Practice of Medicine.  Appleton-Century-Crofts, New York, 1977.

 

Friedel, R.O. and Eisdorfer, C.:  Developmental psychopharmacology:  Childhood and Adolescence.  In M. Jarvik (ed.), Psychopharmacology in the Practice of Medicine.  Appleton-Century-Crofts, New York, 1977.  

 

Friedel, R.O. and Raskind, M.A.:  Psychopharmacology of aging.   In M.F. Elias, B.E. Eleftherion and P.K. Elias (eds.).  Special Review of Experimental Aging Research:  Progress in Biology.  E.A.R., Inc., Bar Harbor, 105-132, 1977.

 

Friedel, R.O.:  Pharmacokinetic factors affecting the action of psychotherapeutic agents in aged patients.  In C. Eisdorfer and R.O. Friedel (eds.).  Cognitive and Emotional Disturbances in the Elderly: Clinical Issues.  Year Book Medical Publishers, Chicago, 139-149, 1977.

 

Eisdorfer, C. and Friedel, R.O. (eds.):  Cognitive and Emotional Disturbances in the Elderly: Clinical Issues.  Year Book Medical Publishers, Chicago, 1977.

 

Friedel, R.O.:   The pharmacotherapy of depression in the elderly:  Pharmacokinetic considerations.  In Cole, J.O. and Barrett, J.E. (eds.), Psychopathology in the Aged.  Raven Press, New York, 157-165, 1980.

 

Friedel, R.O. (ed.): The Borderline Patient:  Diagnosis and Management.  Biomedical Information Co., New York, 1981.

 

Friedel, R.O.:  Relationship of plasma levels of benzodiazepines and clinical response:  A critical review.  In E. Usdin (ed.), Clinical Pharmacology in Psychiatry, Elsevier North Holland, Inc., New York, 269-275, 1981.

 

Friedel, R.O.:  The effects of age on the pharmacology of tricyclic antidepressants.  In A. Raskin, D.S. Robinson, and J. Levine (eds.), Age and the Pharmacology of Psychoactive Drugs, Elsevier North Holland, Inc., New York, 125-131, 1981.

 

Friedel, R.O.:  The diagnosis and management of depression in the elderly patient.  In C. Eisdorfer and W.E. Fann (eds.), Psychopharmacology and Aging, Springer Publishing Co., New York, 1982.

 

Friedel, R.O.:  Affective disorders in the geriatric patient.  In Grinspoon, L. (ed.), Psychiatry 1983, The American Psychiatric Association Annual Review.  American Psychiatric Association Press, Inc., Washington, D.C. 118-130, 1983.

 

Friedel, R.O.:  Clinical predictors of treatment response:  An update.  In Davis, J.M. and Maas, J.W. (eds.), The Affective Disorders.  American Psychiatric Press, Inc., Washington, D.C., 379-384, 1983.

 

Friedel, R.O.:  The therapeutic value, limitations and hazards of treatment of psychiatric disorders with benzodiazepines.  In Roth, M., R. Noyes Jr., and G.D. Burrows (eds.), Handbook of Anxiety, Vol. 1: Biological, Clinical and Cultural Perspectives.   Elsevier Science Publishers B.V., 385-397, 1986.

 

Friedel, R.O. Borderline Personality Disorder.  In Baxter, L.R. and Friedel, R.O. (eds), Current Psychiatric Diagnosis and Treatment. Williams and Wilkins, Philadephia, 28-29, 1998